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Hollywood heavyweight Mo’Nique is not holding back. The comedienne pulled up at her Apollo Theater Mother’s Day show this past weekend and took direct aim at entertainment biz juggernauts Lee Daniels, Tyler Perry and Oprah Winfrey.

Footage from her comedy show has surfaced and shows her going directly at the trio.

“I was not blackballed. I was whiteballed by some black d*cks who had no balls. Thank-you would be Mr. Lee Daniels. Thank-you Mr. Tyler Perry. Thank-you Ms. Oprah Winfrey. No baby, I wasn’t blackballed, I was f*cked up by some n*ggas who had no balls. And see I know they about to say, ‘Mo’Nique, you talk too motherf*cking much.’ It would kill me not to say the real sh*t. It would ‘kill’ me not to say the real sh*t. You are ‘not’ paying me equally. You are ‘not’ treating me fairly. So y’all can suck my d*ck if I had one.”

Back in 2015, Mo’Nique revealed she nearly landed a role on Daniels’ hit “Empire” TV show.

Mo’Nique told host Sway Calloway that last year, “Empire” executive producer and writer Lee Daniels called her saying, “You got the role, but you know, there’s some technical stuff — I ain’t never done TV before, so you gotta go through the technical part.” Mo’Nique then produced printed-out emails she said were sent a short time later by Daniels’ camp asking her representatives to coordinate a screen test, before they later announced the deal was dead. (The Wrap)

Daniels later claimed Mo had no one to blame but herself for getting blackballed.

The director said, “She’s brilliant, and I like working with brilliant people…She was making unreasonable demands, and she wasn’t thinking — this was when reverse racism was happening, I think. I told her, ‘You have to thank the producers of the film, you have to thank the studios.’ And I think she didn’t understand that, and I said, ‘People aren’t going to respond well if you don’t.” (ESSENCE)

Reports claim this is Mo’Nique’s first time publicly airing out Winfrey and Perry.

Mo’Nique had a falling out with “Precious” director Lee Daniels after she won the Oscar for that movie, and she’s made the ‘blackballed in Hollywood’ claim before. But this is the first time she’s lumped in Oprah and Tyler. (TMZ)