New York rapper 50 Cent has no problem poking fun at anyone and everyone. The hip-hop veteran went to social media this week to fire off some playful shade at Dipset’s Juelz Santana.

50 went to Instagram and tossed up a savage meme about staying up late with Santana’s teeth at the core of the joke.

50 went to Instagram last November to acknowledge Santana’s grill.

The same week, Santana responded to Fif’s teeth trolling with a selfie.

Last year, buzz developed about Santana possibly missing teeth with clues showing up in Dipset’s “Sauce Boyz” video.

Up until his verse, Juelz seemingly stays away from the camera as Cam’Ron, Jim Jones and Freekey Zekey perform in suits and bow ties. However, once his hook and verse come up, Juelz appears to rap his lyrics with little movement from his lips. Upon closer review, pictures show that the rapper is missing his two front teeth. Santana previously addressed his missing teeth during an interview on TRL. (The Hollywood Unlocked)